Genome-centric investigation of bile acid-metabolizing microbiota in chickens and their association with <i>Eimeria tenella</i> and <i>Salmonella typhimurium</i> infections.

ABSTRACT:

Introduction

Bile acid (BA) metabolism by gut microbiota plays a crucial role in host health by influencing nutrient absorption, immune responses, and resistance to pathogens. Elucidating how enteric infections disrupt the BA-microbiota axis is crucial for advancing microbiota-based therapeutics, precision nutrition, and post-antibiotic disease control strategies.

Methods

We reconstructed 9,990 high-quality microbial genomes from the gut microbiota of chicken and performed genome-resolved metabolic profiling. Comparative analyses were conducted across host species, including humans and pigs. Also, 135 intestinal samples collected from different regions of the chicken gut were analyzed. Additional samples from chickens infected with Salmonella typhimurium and Eimeria tenella

SUBMITTER: Shang KM 

PROVIDER: S-EPMC12575232 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature