Aperiodic brain activity changes in patients with stroke following virtual reality-based upper limb robotic rehabilitation: a pilot Randomized Controlled Trial.

ABSTRACT:

Introduction

Stroke-related brain changes have traditionally been studied through oscillatory electroencephalographic (EEG) activity, but recent evidence highlights the value of aperiodic components. This pilot randomized controlled trial aimed to assess stroke-related aperiodic EEG changes following virtual reality-based robotic rehabilitation using the Spectral Exponent Index (SEI).

Methods

Nineteen patients with subacute stroke were randomized to unilateral (n = 9) or bilateral (n = 10) upper limb training with a robotic exoskeleton (30 sessions). EEG was recorded at rest before (T0), after (T1), and at 1-week follow-up (T2). SEI was computed for hemispheric and sensorimotor clusters, in affected (AH) and unaffected (UH) hemispheres. Clinical evaluation was

SUBMITTER: Mauro MC 

PROVIDER: S-EPMC12575235 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature