<i>Lacticaseibacillus rhamnosus</i> CBT LR5 with skim milk alleviates scopolamine-induced cognitive impairment in mice.

ABSTRACT:

Introduction

Emerging evidence highlights the gut-brain axis as a pivotal pathway linking gastrointestinal health with cognitive function, particularly in neurodegenerative conditions such as Alzheimer's disease (AD).

Methods

This study investigated the cognitive-enhancing effects of the probiotic strain Lacticaseibacillus rhamnosus CBT LR5 (LR5), alone or in combination with skim milk, in a mouse model of scopolamine-induced cognitive impairment. The cognitive functions were evaluated using the novel object recognition test (NOR) and the passive avoidance test (PAT).

Results

The results demonstrated that the oral administration of LR5, especially when combined with skim milk, significantly ameliorated scopolamine-induced cognitive deficits. Mechanistically, tr

SUBMITTER: Bae HJ 

PROVIDER: S-EPMC12575242 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature