Low rate of infectious mortality omitting fluoroquinolone prophylaxis in high-risk hematological patients, a single centre experience.

ABSTRACT:

Introduction

In hematological patients treated with intensive chemotherapy (CHT), febrile neutropenia (FN) is the primary cause of non-relapse mortality (NRM) due to infections that occur during prolonged neutropenia. Fluoroquinolone (FQ) prophylaxis is still recommended by several guidelines for neutropenic patients because it helps reduce bacterial infection rates and fever episodes, although it does not affect infection-related mortality (IRM). However, in the era of multi-drug resistance (MDR), the use of FQs should be evaluated carefully.

Methods

We present a retrospective, single-center study based on real-life data that includes 512 intensive chemotherapy treatments and the occurrence of prolonged neutropenia in 236 high-risk (HR) hematological patients treated withou

SUBMITTER: Santoni A 

PROVIDER: S-EPMC12575246 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature