Nonlinear association between triglyceride-glucose index and risk of hyperuricemia in early-stage cardiovascular-kidney-metabolic syndrome: a cross-sectional study of United States population.

ABSTRACT:

Objective

Cardiovascular-kidney-metabolic (CKM) syndrome represents a critical intersection of cardiovascular, renal, and metabolic disorders, emphasizing the importance of early risk stratification and intervention. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has shown promise in predicting cardiometabolic risk. However, its association with hyperuricemia in early-stage CKM syndrome remains uncertain.

Methods

This study analyzed data from 14,716 adult participants in the NHANES 2005-2018 dataset. A complex survey weight design and multiple imputation techniques were utilized to address missing data. The relationship between the TyG index and hyperuricemia was examined using generalized additive models and piecewise regression, with multiv

SUBMITTER: Chen X 

PROVIDER: S-EPMC12575291 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature