The association between the adenoid microbiome and chronic otitis media with effusion in children differs according to age.

ABSTRACT:

Introduction

Chronic otitis media with effusion (COME) can adversely affect childhood development, and while the adenoid has been considered a reservoir for bacterial pathogens contributing to the pathogenesis of COME, the role of the adenoid microbiome in COME remains unclear. This study analyzed both the adenoid and gut microbiome in children with and without COME to identify their potential roles in the disease's pathogenesis.

Methods

Adenoid samples were collected during surgery for adenoid microbiome analysis, while fecal samples were collected for gut microbiome analysis. Microbiome was analyzed using whole metagenome sequencing and subsequent bioinformatic analysis.

Results

A significant association between the adenoid microbiome and COME was detected, while no

SUBMITTER: Jo JW 

PROVIDER: S-EPMC12575324 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature