Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.

ABSTRACT:

Background

Sini San, from the traditional Chinese medicine classic Treatise on Exogenous Febrile Disease, has been reported to improve anxiety and depressive symptoms in clinical practice and exhibits certain anti-inflammatory effects. Studies have shown that the inflammatory response is not merely a concomitant feature of depression but actively contributes to its pathogenesis via neuroimmune mechanisms. However, the underlying mechanism remains unclear.

Aim

This study aimed to evaluate the antidepressant effect and inflammatory profile of Sini San in chronic unpredictable mild stress (CUMS)-induced rats and to explore its potential mechanism.

Methods

The primary active ingredients, targets, and pathways of Sini San in treating depression were determined throu

SUBMITTER: Zeng JW 

PROVIDER: S-EPMC12575371 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature