Global burden, regional disparities, and future projections of hypertensive kidney disease in older adults: analysis of GBD 1990-2021 data.

ABSTRACT:

Aims

Hypertensive kidney disease (HKD) contributes significantly to global morbidity and mortality. This study evaluated the burden of HKD in older adults (≥60 years) across 204 countries from 1990 to 2021 and projected trends to 2045.

Methods

Data from the Global Burden of Disease Study 2021 were used to estimate HKD prevalence, incidence, mortality, and disability-adjusted life years (DALYs). Age-standardized rates (ASRs) were calculated with 95% uncertainty intervals (UIs). Temporal trends were analyzed using Joinpoint regression. Slope and concentration indices quantified health inequality. Decomposition and frontier analyses explored burden drivers. Future projections were made using Nordpred-based Bayesian age-period-cohort models. Sensitivity analyses assessed model r

SUBMITTER: Li J 

PROVIDER: S-EPMC12575384 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature