Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics.

ABSTRACT: B cell development in early life sets the stage for how the adaptive immune system will function. Although little is known about B cell biology in children, especially from tissue-residing B cells, it has been previously reported that children generally possess more naive B cell repertoires with less somatic hypermutation and fewer expanded clones compared to adults. In this paper, we move beyond these findings by studying how clonal selection differs between children and adults from both blood and tissue-residing B cells. By integrating deep sequencing data of immunoglobulin heavy chains from genomic DNA from extracted tissues and blood of 15 children and 9 adults across multiple datasets, we demonstrate that B cell repertoires in children are not only less mutated, but also undergo reduc

SUBMITTER: Hsiao T 

PROVIDER: S-EPMC12575387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature