Performance of Donor-Derived Cell-Free DNA in Surveillance and For-Cause Biopsies in Pediatric Kidney Transplant Recipients.

ABSTRACT:

Background

Donor-derived cell-free DNA (dd-cfDNA), a biomarker demonstrated to increase with allograft injury, has been considered a possible diagnostic tool for allograft rejection in place of the current gold standard which is invasive kidney biopsies. We tested whether dd-cfDNA levels were predictive of rejection in our single-center cohort of pediatric kidney transplant (KT) recipients.

Methods

All primary pediatric KT recipients that had a dd-cfDNA level obtained within a month of any kidney biopsy, either surveillance or for-cause were included. Descriptive analysis was performed stratified by rejection status. Univariate analysis was performed to assess the association between median dd-cfDNA levels and rejection by each biopsy time point. dd-cfDNA levels were then fu

SUBMITTER: Kilduff S 

PROVIDER: S-EPMC12575418 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature