Association of biological age acceleration with mortality in adults with diabetes or prediabetes: a mediating role of physical activity.

ABSTRACT:

Background

We sought to investigate the association between biological age (BA) acceleration and mortality among adults with diabetes or prediabetes and to assess whether physical activity mediates this association.

Methods

We included 7,337 participants with diabetes or prediabetes from the 1999-2018 National Health and Nutrition Examination Survey. BA was estimated using the Klemera-Doubal method (KDM). BA acceleration was defined as the residual difference between the estimated BA and chronological age. Cox proportional hazards models were used to examine the association between KDM-BA acceleration and mortality. The mediating effect of physical activity were evaluated to investigate the potential mechanism of the associations between BA acceleration and mortality.

Res

SUBMITTER: Wu N 

PROVIDER: S-EPMC12575468 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature