Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load.

ABSTRACT: Alpha-synuclein (α-syn) deposits are common in around half of the Alzheimer's disease (AD) cases. While direct and indirect protein interactions are suggested, the relationships between different protein aggregates remain poorly understood. Here, we aimed to characterize α-syn, amyloid beta (Aβ), and tau load distributions of AD patients. Protein deposits were automatically quantified with random forest pixel classifiers in immunohistochemical stains of up to 28 brain regions in 72 brains with advanced AD neuropathological change. α-syn-negative cases were distinguished from amygdala predominant, brainstem predominant, and cortical α-syn-positive cases. Relationships with age, sex, and ApoE genotype were examined. α-syn co-pathology was detected in 60% of AD cases, more frequently, althoug

SUBMITTER: Neubauer A 

PROVIDER: S-EPMC12575528 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature