Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model.

ABSTRACT:

Purpose

Replicating spinal cord injury (SCI) in large animals is necessary for evaluating translational therapeutics, yet there is currently no commercial, standardized device for inducing SCI. We present the fabrication and testing of a custom impactor device for producing repeatable contusion SCI in porcine models.

Methods

The device was built, and mechanical modeling was utilized for calibration. Benchtop verification measured impact force. Impact velocity and kinetic energy were calculated. The device was used to generate a contusion SCI model in 2 pigs and the results were compared to an uninjured pig. Ultrasound imaging and Hematoxylin-eosin (H&E) staining were used to confirm injury presence. The device was utilized in survival studies requiring a porcine SCI model an

SUBMITTER: Steger L 

PROVIDER: S-EPMC12575548 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature