Reprogramming encapsulins into modular carbon-fixing nanocompartments.

ABSTRACT: Introducing CO₂-concentrating mechanisms (CCM) into C₃ crops represents a major frontier in synthetic biology with potential to enhance photosynthetic efficiency and yields. Despite decades of progress in elucidating CCM components, mechanisms and genetics (including structures of native Rubisco-containing compartments), installing algal pyrenoids or cyanobacterial carboxysomes into plants remains a formidable challenge. This is due to the requirement for chloroplast engineering to facilitate sufficient expression, and specificity of condensate proteins that impedes use of heterologous Rubiscos without extensive genetic redesign. Here, we present a modular streamlined alternative, a synthetic system using encapsulin nanocompartments from Quasibacillus thermotolerans (

SUBMITTER: Szyszka TN 

PROVIDER: S-EPMC12575627 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature