Microtube-integrated chips for modular electrical stimulation and 3D confined neural network growth.

ABSTRACT: In vitro neural networks offer a simplified model to study brain nervous system functions and represent a vital platform for investigating cerebral neural activities. Microelectrode array (MEA) chips are commonly used to construct modular neural networks and enable electrical stimulation and recording for uncovering signal generation and conduction mechanisms. However, conventional two-dimensional (2D) MEA chips face significant limitations, including restricted neuronal growth dimensions and insufficient neuron density. Herein, we present a novel micro-integrated chip featuring a three-dimensional (3D) physical microtube array that facilitates the regulated, confined growth of neurons. The microtube array not only provides a 3D microenvironment for neuronal growth and differentiation but

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC12575633 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature