Multi-modal omics analysis of a paediatric melanoma highlights mechanisms underlying treatment resistance.

ABSTRACT:

Background

Cutaneous malignant melanoma is a common cancer in adults but extremely rare in young children, affecting fewer than one child per million each year in Europe. Because of its rarity, most treatments for children are adapted from adult therapies, despite possible biological differences. This study aimed to explore the molecular features of a rare and aggressive melanoma in a 16-month-old patient to understand disease progression and treatment resistance.

Methods

We studied the tumour and metastases of a patient with a melanoma carrying an NRAS mutation, who received chemotherapy and immune checkpoint inhibitor treatment. The patient died 10 months after diagnosis. We used DNA methylation analysis, single-nucleus RNA sequencing, and deep spatial transcriptomic profi

SUBMITTER: Mucha M 

PROVIDER: S-EPMC12575648 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature