Regulating white blood cell activity through the novel universal receptive system.

ABSTRACT: The understanding of the mechanisms that control key features of immune cells in various disease contexts remains limited, and few techniques are available for manipulating immune cells. Thus, discovering novel strategies for regulating immune cells is essential for gaining insight into their roles in health and disease. In this study, we investigated the potential of the recently described Universal Receptive System to regulate human immune cell functions. This was achieved for the first time by specifically targeting newly discovered surface-bound DNA- and RNA-based receptors on leukocytes using endonucleases and generating "Leukocyte-Tells." Using this approach, 1,496 genes were upregulated, many of which are related to immune cell signaling, migration, endocytosis, and phagocytosis pat

SUBMITTER: Tetz V 

PROVIDER: S-EPMC12575690 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature