Combined effects of insulin resistance and dyslipidaemia on cardiometabolic multimorbidity in Chinese middle-age and older adults: a longitudinal cohort study.

ABSTRACT: Cardiometabolic multimorbidity (CMM), defined as the coexistence of ≥ 2 cardiometabolic diseases, is a significant public health burden. Insulin resistance and dyslipidaemia are key risk factors for CMM; however, their combined effects remain unexplored. As such, the present study investigated the individual and combined associations of the estimated glucose disposal rate (eGDR, a marker of insulin resistance) and remnant cholesterol (RC [reflecting dyslipidaemia]) with the incidence of CMM. A longitudinal cohort of 7094 participants ≥ 45 years of age from the China Health and Retirement Longitudinal Study was analysed. Participants were divided into four groups based on the optimal cut-off values for eGDR (9.13 mg/kg/min) and RC (13.53 mg/dL). Cox regression models were used to evaluate a

SUBMITTER: Wang H 

PROVIDER: S-EPMC12575698 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature