CTTN overexpression in HNSCC inhibits Anoikis-apoptosis.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent and heterogeneous malignancy. Normal cells maintain their homeostasis through Anoikis, and tumor cells enhance their own invasion and migration by resisting Anoikis. The search for biomarkers of resistance to Anoikis in head and neck tumors could be helpful in evaluating the prognosis of patients as well as in finding therapeutic targets for HNSCC due to the lack of more definitive biomarkers in HNSCC. HNSCC cells were cultured in suspension, and HNSCC cells were found to undergo apoptosis after losing the support of ECM.LASSO-Cox regression analysis was applied to the TCGA-HNSC cohort to evaluate the prognostic value of apoptosis-associated genes, resulting in the construction of an apoptosis-related prognostic model (CTT

SUBMITTER: Shen ZZ 

PROVIDER: S-EPMC12575726 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature