Functional specialisation of multisensory temporal integration in the mouse superior colliculus.

ABSTRACT: Our perception of the world depends on the brain's capacity to integrate information from multiple senses, with timing differences serving as crucial cues for binding or segregating cross-modal signals. The superior colliculus (SC) is a central hub for such integration, yet the contributions of its distinct regions remain poorly understood. Here we show, from recordings of over 5000 neurons in awake mice, that multisensory neurons reliably encode audiovisual delays through nonlinear integration of auditory and visual inputs. This nonlinearity enhances the precision of delay representation, with posterior-medial SC populations representing the peripheral sensory field showing superior temporal discriminability. Connectivity analyses reveal stronger coupling in the medial SC and function-spe

SUBMITTER: Bianchini G 

PROVIDER: S-EPMC12575753 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature