Liver dysfunction triggers early Alzheimer's pathology in an adult rat model of chronic liver disease.

ABSTRACT: Emerging evidence links liver dysfunction to Alzheimer's disease (AD), though few studies have investigated this connection. While cirrhosis is associated with cognitive impairment, its underlying mechanisms remain poorly understood. This study aimed to assess the presence of central nervous system (CNS) markers of Alzheimer's disease in a rat model of chronic liver disease. Standard histochemical techniques were employed, including Congo red staining for amyloid-β (Aβ) and Gallyas silver staining for tau pathology. Immunohistochemistry was used to evaluate changes in aquaporin (Aqp1, Aqp4, Aqp9) expression and astrocytic glial fibrillary acidic protein (GFAP) levels. Furthermore, blood concentrations of neurodegeneration markers, neurofilament light chain (NfL), Aβ, phosphorylated tau (p-

SUBMITTER: Braissant O 

PROVIDER: S-EPMC12575788 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature