Safety trial assessing 1.77 cm² H₂O₂ producing electrochemical bandages on healthy human skin.

ABSTRACT: Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented- H₂O₂ (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H₂O₂ in precise, micromolar concentrations for controlled time intervals. Safety of sterile, 1.77 cm² H₂O₂-generating e-bandages loaded with 3M hydrogel containing 0.9% sodium chloride was evaluated on healthy adult forearms. Twenty participant

SUBMITTER: Kies PJ 

PROVIDER: S-EPMC12575839 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature