Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke.

ABSTRACT: Blood biomarkers in stroke patients seek to guide decision-making in clinical practice, but research on those that respond to brain recovery and their relationship with rehabilitation is still limited. Our aim was to explore the value of known neuroplasticity-related molecules, such as endostatin, growth and differentiation factor-10 (GDF-10), urokinase-type plasminogen activator (uPA) and the uPA receptor (uPAR), as blood biomarkers of recovery during poststroke rehabilitation. In an observational, prospective and multicenter study, biomarker levels were assessed after stroke in a cohort of 62 stroke patients with outcome evaluations and blood sampling before starting rehabilitation and during therapy at 1, 3 and 6 months of first visit, and in 43 control subjects. Serum levels were deter

SUBMITTER: Garcia-Rodriguez N 

PROVIDER: S-EPMC12575871 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature