Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression.

ABSTRACT: Colorectal cancer (CRC) is a common malignant tumor of the digestive tract, and chemotherapy resistance along with adverse reactions during treatment present significant challenges in clinical practice. Therefore, there is an urgent need to find effective and low-toxicity therapeutic agents. Ferroptosis, a recently discovered form of cell death, has attracted attention as a potential new cancer treatment strategy. Microwave dynamic therapy (MWDT), as a promising anticancer agent, has been shown to significantly inhibit various malignancies, including CRC. However, the role of MWDT in ferroptosis and its underlying mechanisms have not been fully explored. In this study, we demonstrated that MWDT treatment significantly increased levels of lipid peroxidation (LPO), reactive oxygen species (R

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12575923 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature