The impact of early life stress on patient-reported outcomes in multiple sclerosis.

ABSTRACT:

Background

Early life stress (ELS) has been implicated in the risk of developing autoimmune disorders including multiple sclerosis (MS), but less is known about its relationship to the clinical course of MS.

Objective

Investigate the relationship between ELS and MS patient-reported outcomes (PRO).

Methods

In a single-center, cross-sectional study, persons with MS completed a composite of surveys assessing ELS and PRO including the adverse childhood experiences (ACE) survey, the Childhood Trauma Questionnaire, MS Performance Scales, MS Impact Scale (MSIS-29) and MS Quality of Life (MSQOL-54). Multiple linear regression models were used to assess the associations between ELS and outcomes while adjusting for potential confounding variables.

Results

A total of 133

SUBMITTER: Goldman M 

PROVIDER: S-EPMC12575964 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature