Genetic and molecular assessment of the relationship between smoking and EBV reactivation: A two-sample Mendelian randomization and in-vitro experimental study.

ABSTRACT: ObjectiveTo assess whether modifiable lifestyle factors (particularly tobacco smoking) have a potential causal effect on Epstein-Barr virus (EBV) reactivation proxied by anti-EBV IgG seropositivity using Mendelian randomization (MR), and to explore the underlying mechanism in vitro.MethodsWe performed a two-sample Mendelian randomization (MR) study (retrospective secondary analysis) using de-identified genome-wide association study (GWAS) summary statistics for 83 dietary habits, 5 tobacco smoking behaviors, and 4 sleep traits with anti-EBV IgG seropositivity as the outcome. We further conducted experiments in EBV-positive B-cell lines to examine mechanisms.ResultsGenetically proxied smoking initiation and lifetime smoking were associated with higher odds of anti-EBV IgG seropositiv

SUBMITTER: Xiang W 

PROVIDER: S-EPMC12576057 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature