Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types.

ABSTRACT: Retinitis pigmentosa is a hereditary disease-causing progressive degeneration of rod and cone photoreceptors, with no effective therapies. Using rd10 mice, which mirror the human condition, we examined its disease progression. Rods deteriorate by postnatal day (P) 45, followed by cone degeneration, with most photoreceptors lost by P180. Until then, retinal ganglion cells (RGCs) remain light-responsive under photopic conditions, despite extensive outer retinal remodelling. However, it is still unknown if distinct functional RGC types alter their activity or are even lost during disease progression. Here, we asked if and how the response diversity of functional RGC types changes with rd10 disease progression. At P30, we identified all functional wild-type RGC types also in rd10 retinae, sugg

SUBMITTER: Dyszkant N 

PROVIDER: S-EPMC12576309 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature