Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster.

ABSTRACT: De novo genes, which originate from noncoding DNA, are known to have a high rate of turnover over short evolutionary timescales, such as within a species. Thus, their expression is often lineage- or genetic background-specific. However, little is known about their levels and breadth of expression as populations of a species diverge. In this study, we utilized publicly available RNA-seq data to examine the expression of newly evolved open reading frames (neORFs) in comparison to non- and protein-coding genes in Drosophila melanogaster populations from the derived species range in Europe and the ancestral range in sub-Saharan Africa. Our datasets included two adult tissue types as well as whole bodies at two temperatures for both sexes and three larval/prepupal developmental stages in a sing

SUBMITTER: Glaser-Schmitt A 

PROVIDER: S-EPMC12576379 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature