Recently Evolved, Stage-Specific Genes Are Enriched at Life-Stage Transitions in Flies.

ABSTRACT: Understanding how genomic information is selectively utilized across different life stages is essential for deciphering the developmental and evolutionary strategies of metazoans. In holometabolous insects, the dynamic expression of genes enables distinct functional adaptations at embryonic, larval, pupal, and adult stages, likely contributing to their evolutionary success. While Drosophila melanogaster (D. melanogaster) has been extensively studied, less is known about the evolutionary dynamics that could govern stage-specific gene expression. To address this question, we compared the distribution of stage-specific genes, that is, genes expressed in temporally restricted developmental stages, across the development of D. melanogaster and Aedes aegypti (A. aegypti). Using tau-scoring, a co

SUBMITTER: Remmel A 

PROVIDER: S-EPMC12576388 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature