Impact of <i>TSC2</i> loss on progression-free survival in uterine carcinosarcoma: A retrospective analysis.

ABSTRACT:

Objective

Uterine carcinosarcoma (UCS) is a rare and aggressive gynecological cancer with high recurrence rates and is associated with a poor prognosis. It is also characterized by a high frequency of copy number alterations (CNAs). This study aimed to determine which gene CNA contributes to progression-free survival (PFS) in patients with UCS to identify potential prognostic biomarkers and therapeutic targets.

Methods

DNA was extracted from formalin-fixed paraffin-embedded tissues of surgical specimens from 24 patients with UCS who were treated at Fujita Health University. Using the PleSSision-Rapid test, the mutation information of 145 cancer genes was analyzed. Oncoplot analysis was used to visualize gene mutation profiles. χ² test, Kaplan-Meier analysis, and l

SUBMITTER: Ichikawa R 

PROVIDER: S-EPMC12576405 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature