Chick early amniotic fluid attenuates lipopolysaccharide-induced acute lung injury.

ABSTRACT: Acute lung injury (ALI) and acute respiratory distress syndrome are major causes of acute respiratory failure and even death. Acute pneumonia can be accompanied by damage to the alveolar epithelium. In vitro functional experiments were performed by constructing inflammatory models in human alveolar epithelial cells. It was found that the chick early amniotic fluid (ceAF) extracted from SPF-grade early chicken embryos could significantly reduce the inflammation of human lung epithelial cells (Calu-3) induced by lipopolysaccharide (LPS) and COVID-19 protein pseudovirus, and reduce the gene expression of inflammatory factors. Pneumonia is one of the most common risk factors for causing ALI. An acute pneumonia model was constructed by LPS inhalation. Tail vein injection of ceAF signific

SUBMITTER: Yin C 

PROVIDER: S-EPMC12576422 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature