A semi-dominant NLR allele regulates growth and disease resistance in wheat.

ABSTRACT: Wheat powdery mildew is a significant threat to wheat production, necessitating the development of disease-resistant varieties as an economically viable and environmentally sustainable strategy. In this study, we investigated a semi-dominant mutant, necrosis leaf (necl), which exhibits spontaneous necrotic lesions and enhanced resistance to powdery mildew. We identified that the necl phenotype is caused by a Lys-to-Glu gain-of-function mutation at position 421 in the coiled-coil nucleotide-binding leucine-rich repeat (CC-NLR) protein TaCNL, through the combination of map-based cloning, transformation, and mutagenesis. Further analysis indicated that the TaCNL mutant enhanced resistance to powdery mildew likely through activation of the phenylalanine catabolic process and increased salicyli

SUBMITTER: Tian S 

PROVIDER: S-EPMC12576435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature