Co-occurrence patterns of esophageal and stomach cancer across 204 countries and territories: a spatial correspondence and systematic analysis.

ABSTRACT:

Background

Esophageal and gastric cancers are common malignant tumors of the digestive tract worldwide, characterized by a substantial disease burden and significant regional disparities. While these cancers share anatomical proximity, risk factors, and pathogenic mechanisms to some extent, there remains a lack of comprehensive and up-to-date global comparative studies on their co-occurrence patterns and burden trends.

Methods

Using primary data from the Global Burden of Disease (GBD) 2021 study, we defined and categorized global co-occurrence patterns of esophageal and gastric cancers based on quartile methods. Descriptive analysis, correlation analysis, age-period-cohort modeling, decomposition analysis, and predictive modeling were employed to thoroughly examine the disea

SUBMITTER: Xu J 

PROVIDER: S-EPMC12576481 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature