Postdiagnosis Statin Use and Breast Cancer Mortality.

ABSTRACT:

Importance

Emerging evidence suggests that cholesterol plays a role in breast cancer (BC) metabolism, raising the possibility that cholesterol-lowering medications, such as statins, may improve BC prognosis.

Objective

To evaluate the association between postdiagnosis statin initiation and BC mortality using an emulated target trial approach.

Design, setting, and participants

This observational cohort study using a target trial framework included 96 924 women diagnosed with stage I to III BC from 2000 to 2021 from Nationwide Danish registries, including the Danish Breast Cancer Group's clinical database and the Danish National Prescription Registry. Women with prior invasive BC or prediagnosis use of cholesterol-lowering medication were excluded. Eligible patients were

SUBMITTER: Harborg S 

PROVIDER: S-EPMC12576488 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature