Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic neuro-degenerative and inflammatory disease causing motor, sensory, and cognitive deficits, including impairments in working memory and attention. These cognitive deficits may arise from an imbalance between excitatory and inhibitory neural activity due to synaptic loss. Recent studies suggest that the aperiodic 1/f slope, a neural marker reflecting excitation/inhibition (E/I) balance, could serve as a biomarker for cognitive control. This study examines 1/f slope modulation during cognitive tasks in people with MS and healthy controls to investigate its potential as a paradigm-independent marker of cognitive control. We analyzed the Magnetoencephalography (MEG) data collected from 126 participants: 44 healthy controls (HCs), 61 people with MS not treat

SUBMITTER: Akbarian F 

PROVIDER: S-EPMC12576845 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature