Combined and progressive effect of frailty and sarcopenia on the risk of cardiovascular disease in middle-aged and older adults.

ABSTRACT:

Background

Frailty and sarcopenia are two related conditions, but how they lead to cardiovascular disease (CVD) remain unclear. The study aimed to investigate the combined and progressive effect of them.

Methods

The data were from China Health and Retirement Longitudinal Study (CHARLS). Frailty status was evaluated by the Rockwood frailty index and sarcopenia status was classified according to the Asia Working Group for Sarcopenia 2019.

Results

A total of 7187 participants aged over 45 years (49.41% male; mean age 57.38 ± 8.41 years) were enrolled in 2011. Among them, 4265 individuals without CVD events between 2011 and 2015 were included in the analysis of dynamic changes. Over the nine-year period, both frailty and sarcopenia status were independently associated wit

SUBMITTER: Liu M 

PROVIDER: S-EPMC12576861 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature