Distinct gut microbial species, but not phylum-to-genus composition, associate with insulin resistance: a unique perspective from the Kazakh population.

ABSTRACT:

Objectives

Links between gut microbiota and insulin resistance (IR) vary across populations. We profiled the fecal microbiota of Kazakh adults to test whether community composition associates with IR at broad (phylum → genus) and species levels.

Methods

In a cross-sectional case control study (N = 200; IR = 183, controls = 17), TyG indexed IR status. 16S rRNA sequencing (two primer pools; nine hypervariable regions) characterized taxa. After CSS normalization, we compared presence/absence across groups (χ²) and modeled species with univariate and multivariable logistic regressions, using absence of each species as the predictor.

Results

High-level composition did not differ between IR and controls (phylum, class, family, genus; all p > 0.05).

SUBMITTER: Abildinova GZ 

PROVIDER: S-EPMC12576892 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature