Treatment effects of fibrinogen concentrates vs. cryoprecipitate for correcting hypofibrinogenemia in cardiac surgery patients: a systematic review and meta-analysis.

ABSTRACT:

Background

Hypofibrinogenemia in cardiac surgery increases bleeding risk, but the efficacy and safety of fibrinogen concentrate vs. cryoprecipitate remain unclear. This meta-analysis compares the patient-important outcomes associated with the use of fibrinogen concentrate vs. cryoprecipitate for the management of acquired hypofibrinogenemia in cardiac surgery.

Methods

Medline, Embase, Cochrane Library, and Transfusion Evidence Library were searched from their inception until June 2024. Eligible studies included randomized clinical trials (RCTs). Effect estimates were synthesized using risk ratios (RR) and standardized mean differences (SMD), along with their corresponding 95% confidence intervals (CIs).

Results

We analyzed 4 RCTs (945 participants: 823 adults, 122 chi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12576893 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature