Infectious complications in Philadelphia-Negative adolescent and young adult acute lymphoblastic leukemia patients in the era of pediatric-inspired regimen.

ABSTRACT:

Introduction

Pediatric acute lymphoblastic leukemia (ALL) has a cure rate above 90%, but outcomes in adult remain poor, with 3-year survival around 40%. Adolescents and young adults (AYAs) fall between these groups, often facing worse disease features and treatment-related risks. While pediatric-inspired regimens improve survival in AYAs, they also raise the issue of infection due to treatment intensity.

Methods

A retrospective analysis was conducted on AYA-ALL patients treated at Chiang Mai University Hospital from 1 January 2007 to 31 December 2023. Data were accessed for research purpose from 10 January 2024 to 31 December 2024. Patients received either pediatric-inspired (TPOG) or adult regimens (Hyper-CVAD or GMALL). Infections were classified as clinically (CDI) or mic

SUBMITTER: Vongngakesone P 

PROVIDER: S-EPMC12576904 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature