Polycaprolactone/chitosan core-shell nanoparticles for the acceleration of second-degree burn healing in CD1 mice.

ABSTRACT: Burn injuries are a major global health problem, and finding treatments for them is critical. Therefore, we aimed to design a drug delivery formulation for tea-tree oil comprising polycaprolactone/chitosan core-shell nanoparticles in order to accelerate the wound healing process in second-degree burns induced in CD1 mice. The present work is a continuation of our previously reported results on the antimicrobial and anti-inflammatory activity of the suggested nanomaterial. The nanoparticles (NPs) were optimized and characterized using FTIR spectroscopy, electron microscopy, dynamic light scattering, and zeta potential measurement. The investigations revealed that the best NP composition is 2 : 1 (PCL/CS, w/w), which showed an average particle size of 10.1 nm and a spherical core-shell struc

SUBMITTER: Saleh AH 

PROVIDER: S-EPMC12576911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature