Molecular Mechanisms Explaining Neuroanatomical Subtypes in Major Depressive Disorder: Insights From Cortical Morphometric Inverse Divergence.

ABSTRACT: Major depressive disorder (MDD) exhibits substantial neurobiological heterogeneity that complicates treatment selection and mechanistic understanding. While conventional group-level analyses identify diverse structural alterations, they obscure clinically relevant individual differences. We employed heterogeneity through discriminant analysis (HYDRA) clustering to decompose morphometric inverse divergence (MIND) network patterns into distinct neuroanatomical subtypes and examined their molecular underpinnings. We analyzed MIND network data from 240 Japanese individuals with MDD and 367 healthy controls using unsupervised clustering. Subtype-specific alterations were mapped onto neurotransmitter receptor density distributions, and transcriptomic data from the Allen Human Brain Atlas were in

SUBMITTER: Ge Y 

PROVIDER: S-EPMC12576961 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature