Topographic Variation in Human Neurotransmitter Receptor Densities Explains Differences in Intracranial EEG Spectra.

ABSTRACT: Brain function and its failures arise from dynamical patterns of neuronal activity shaped by synaptic neurotransmission. Both neurotransmitter receptor expression and neuronal population dynamics show a remarkable regional variability across the human cortex. We leverage this functional specialisation to characterise the relationship between receptor architectonics and electrophysiological signals. Using dynamic causal modelling (DCM), we fitted neural mass models to a normative set of intracranial EEG data. Subsequently, Bayesian model comparison helped to evaluate whether models improved when equipped with constraints on synaptic connectivity, based on regional neurotransmitter receptor densities. The results show that dynamic causal models generated region-specific intracranial EEG spec

SUBMITTER: Stoof UM 

PROVIDER: S-EPMC12576962 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature