Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.

ABSTRACT: The observation that the risk of developing Alzheimer's disease is reduced in individuals with high premorbid cognitive functioning, higher educational attainment, and occupational status has led to the 'cognitive reserve' hypothesis. This hypothesis suggests that individuals with greater cognitive reserve can tolerate a more significant burden of neuropathological changes before the onset of cognitive decline. The underpinnings of cognitive reserve remain poorly understood, although a shared genetic basis between measures of cognitive reserve and Alzheimer's disease has been suggested. Using the largest samples to date and novel statistical tools, we aimed to investigate shared genetic variants between Alzheimer's disease, and measures of cognitive reserve; cognition and educational attai

SUBMITTER: Jaholkowski P 

PROVIDER: S-EPMC12576965 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature