Parental clinical manifestation association with newborn immune senescence and telomere biology in Pakistan.

ABSTRACT:

Objective

This study investigates the association of parental clinical manifestations with newborn telomere biology and immune senescence markers, utilising 204 parent-newborn triads in Karachi, Pakistan. The demographic data collection was followed by quantification of telomere length (TL) using quantitative PCR, while Sanger sequencing was performed to analyse variants in telomerase genes [Telomere Reverse Component (TERC) and Telomerase Reverse Transcriptase (TERT)]. Moreover, flow cytometry was used to analyse immune senescence markers CD57 and Killer cell lectin-like receptor G1 (KLRG1).

Results

The study revealed that immune senescence markers (CD57⁺KLRG1⁺) (3.5 ± 5.49, 3.1 ± 1.27) were significantly overexpressed in newborns from the diseased parent (diabetes, hyperte

SUBMITTER: Farrukh S 

PROVIDER: S-EPMC12577043 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature