Interaction between physical frailty and sleep quality on risk of migraine in later life: a cohort study of over 350,000 participants.

ABSTRACT:

Background

Frailty was associated with neurological disorders, but has not been extrapolated to migraine. It's unclear whether maintaining healthy sleep mitigates this association. We examined the independent, joint, and interactive relationships between frailty status and sleep quality and migraine risk.

Methods

356,326 participants from the UK Biobank without migraine at baseline were included. The five-component Fried phenotype was used to assess frailty status and categorized participants as non-frail, pre-frail, and frail. A five-factor sleep questionnaire was employed to quantify sleep quality and categorize individuals into poor, intermediate, and healthy sleep. Cox proportional hazard models were applied to calculate the hazard ratios (HRs) and 95% confidence interva

SUBMITTER: Hu W 

PROVIDER: S-EPMC12577047 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature