Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits.

ABSTRACT:

Background

A comprehensive and representative reference database is crucial for accurate taxonomic and functional profiling of the human gut microbiome in population-level studies. However, as approximately 70% of current microbial reference data originate from European and North American populations, other regions, including East Asia-and particularly China-remain significantly underrepresented.

Methods

We constructed the human Gut Microbiome Reference (GMR), comprising 478,588 high-quality microbial genomes from Chinese (247,134) and non-Chinese (231,454) populations. Species-level clustering and protein annotations were performed to characterize microbial diversity and function. We further integrated novel microbial genomes into taxonomic profile database and validated th

SUBMITTER: Dong Q 

PROVIDER: S-EPMC12577051 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature