Pediatric NUT carcinoma: a patient series and literature review.

ABSTRACT:

Background

Nuclear protein in testis (NUT) carcinoma (NC) in children is a rare tumor with highly aggressive nature and dismal prognosis.

Methods

We conducted a retrospective analysis of case series towards NC-patients aged 0-18 years treated at the Department of Pediatric Oncology, Sun Yat-sen University Cancer Center between July 2021 and September 2022. The primary end point was to explore the efficacy of therapy. The clinical and pathological characteristics of the patients were also analyzed. The last follow-up date was March 1, 2025.

Results

The ages of the patients ranged from 8 to 18 years. The tumor sites were head and neck in four patients and vulva in one patient. Three patients underwent upfront surgical resections, followed by chemotherapy(CHT) ± radiothe

SUBMITTER: You Y 

PROVIDER: S-EPMC12577070 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature