An inactivated vaccine against acquired Toxoplasma gondii infection in pigs as a tool to minimize the zoonotic transmission risk.

ABSTRACT: Toxoplasma gondii, a zoonotic protozoan parasite, represents a major threat to public health and food safety worldwide, particularly through the consumption of undercooked or raw pork containing tissue cysts. Controlling T. gondii infection in pigs is therefore critical to reduce zoonotic transmission. This study evaluated a novel inactivated vaccine formulated with antigens from the Type III TgPigSp1 isolate, comprising both tachyzoite and bradyzoite stages, and adjuvanted with Quil-A. Safety, immunogenicity, and efficacy were assessed first in a murine model as proof of concept and subsequently in piglets challenged with 1000 oocysts of the heterologous Type II-PRU TgShSp1 isolate. The vaccine showed no systemic adverse effects in either model, and an absence of local reactions was obser

SUBMITTER: Largo-de la Torre A 

PROVIDER: S-EPMC12577071 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature