Dose-response relationship of physical activity and sedentary time with mortality in people with chronic obstructive pulmonary disease: an analysis of UK biobank accelerometer cohort.

ABSTRACT:

Background

The COPD guidelines recommend engaging in regular physical activity and reducing sedentary time (ST), but little is known about the optimal or minimal dose of physical activity and ST. This study aimed to quantify the prospective dose-response relationships between daily time spent in moderate to vigorous physical activity (MVPA), light physical activity (LPA), ST and mortality, and examine the theoretical consequences of replacing ST with equal time of MVPA or LPA.

Methods

A population-based cohort study of 1,551 individuals with COPD enrolled in the UK Biobank. MVPA, LPA, ST were measured with the wrist-worn Axivity AX3 accelerometer. All-cause mortality was obtained through the linkage to death registries. Restricted cubic splines were used to assess the dose r

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12577078 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature