Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation.

ABSTRACT: Ageing is accompanied by a decline in immune function, associated with susceptibility to infections and malignancies, and reduced vaccine efficacy. These immunological changes, affect multiple components of the immune system, particularly T lymphocytes, which exhibit altered subset distributions and accumulate senescent features. CD57, a surface glycoprotein expressed on T cells, has emerged as a potential marker of terminal differentiation and senescence used for immunomonitoring in infection or cancer contexts. However, the use of CD57 as a marker of T cell senescence remains unclear. To investigate this, we analyzed CD57 expression on CD8⁺ and CD4⁺ T cells in healthy donors from two independent cohorts, considering cellular differentiation, age, cytomegalovirus sta

SUBMITTER: Autaa G 

PROVIDER: S-EPMC12577104 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature